Alkaloids identified in Kratom Mitragyna Speciosa

Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa, thr Kratom leaf. Some of the alkaloids in the list below still need to be studied in more detail to determine their potential activity.

  • Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.
  • Akuammigine
  • Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.
  • Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.
  • Corynoxeine: Calcium channel blocker.